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課程名稱 |
環境基因與表基因
Environmental Genetics and Epigenetics |
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開課學期 |
100-2 |
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授課對象 |
公共衛生學院 環境衛生研究所 |
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授課教師 |
劉貞佑 |
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課號 |
EH7031 |
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課程識別碼 |
844 M1350 |
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班次 |
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學分 |
2 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三7,8(14:20~16:20) |
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上課地點 |
公衛208 |
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備註 |
總人數上限：20人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
環境因子對人體的影響因人而異，本課程以相關文獻為參考範例，針對環境基因表基因對人體的交互影響以及研究方法作討論
The interaction between genes and environmental exposures plays a major role in disease development. This course will focus on the underlying science of gene-exposure interactions and will use examples of such interactions to evaluate the investigations. |
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課程目標 |
瞭解環境分子流行病學的研究方法並培養執行相關研究的能力 |
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課程要求 |
英文期刊文獻閱讀及課堂討論 |
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預期每週課後學習時數 |
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Office Hours |
另約時間 備註： By appointment |
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指定閱讀 |
1. Human Molecular Genetics, 3rd Edition (2003) by Tom Strachan and
Andrew Read, Garland Science/Taylor & Francis Group
2. Genetic Analysis of Complex Disease (Paperback) 2nd edition (2006) by
Jonathan L. Haines, Margaret A. Pericak‐Vance, Wiley‐Liss Publishers
3. 其他參考資料隨堂發給 |
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參考書目 |
Human Molecular Genetics, 3rd Edition (2003) by Tom Strachan and
Andrew Read, Garland Science/Taylor & Francis Group
2. Genetic Analysis of Complex Disease (Paperback) 2nd edition (2006) by
Jonathan L. Haines, Margaret A. Pericak‐Vance, Wiley‐Liss Publishers
3. The Epigenome: Molecular Hide and Seek (2003) by Stephan Beck, Alexander Olek, Wiley-VCH Publisher |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
In-class discussion |
20% |
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2. |
Homework |
20% |
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3. |
Oral presentation |
20% |
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4. |
Mid-term exam |
10% |
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5. |
Written report |
30% |
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週次 |
日期 |
單元主題 |
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第1週 |
2/22 |
Introduction and general concepts |
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第2週 |
2/29 |
Types & mechanisms of genetic susceptibility |
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第3週 |
3/07 |
haplotype and tagSNPs |
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第4週 |
3/14 |
Molecular and genetic epidemiology |
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第5週 |
3/21 |
Studying Gene-environment Interactions - What to be aware of |
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第6週 |
3/28 |
Technologies |
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第7週 |
4/04 |
Holiday |
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第8週 |
4/11 |
Mid-term exam |
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第9週 |
4/18 |
Environmental exposure and human genetic variation |
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第10週 |
4/25 |
Epigenetics: Introduction and general concepts |
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第11週 |
5/02 |
Ghost in your genes |
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第12週 |
5/09 |
Environmental instructions for the genome; techniques |
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第13週 |
5/16 |
Prenatal and early-life exposures; dietary determinants of epigenetic states |
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第14週 |
5/23 |
Epigenetics and cancer |
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第15週 |
5/30 |
Epigenetics alterations of aging, cardiovascular disease, inflammation and respiratory disease |
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第16週 |
6/06 |
Student presentation |
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第17週 |
6/13 |
Discussion |
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第18週 |
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Final exam week |
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